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Article

Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma.

Frontiers in endocrinology - 1 Jan 2024

Nanba Kazutaka, Blinder Amy R, Udager Aaron M, Hirokawa Yuusuke, Miura Takayoshi, Okuno Hiroshi, Moriyoshi Koki, Yamazaki Yuto, Sasano Hironobu, Yasoda Akihiro, Satoh-Asahara Noriko, Rainey William E, Tagami Tetsuya

Abstract excerpt

Double somatic mutations in CTNNB1 and GNA11/Q have recently been identified in a small subset of aldosterone-producing adenomas (APAs). As a possible pathogenesis of APA due to these mutations, an association with pregnancy, menopause, or puberty has been proposed. However, because of its rarity, characteristics of APA with these mutations have not been well characterized. A 46-year-old Japanese woman presented...

Read the complete abstract on PubMed

Topics

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Share to Adenoma
Share to Adrenocortical Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldosterone

Share to beta Catenin

Share to Cytochrome P-450 CYP11B2

Share to GTP-Binding Protein alpha Subunits

Share to Hyperaldosteronism

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Source

Open in PubMed Open full text

Identifiers

PMID: 38505749
DOI: 10.3389/fendo.2024.1286297
PMCID: PMC10948454

Genes

CTNNB1
GNA11
CYP11B2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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