Article
Newly Identified BRAF Mutation in Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2016
Arnoux Fanny, Fina Frederic, Lambert Nathalie, Balandraud Nathalie, Martin Marielle, Ouafik L'Houcine, Kanaan Sami B, Roudier Jean, Auger Isabelle
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA)-associated autoantibodies include those directed at the kinase site of BRAF (v-Raf murine sarcoma viral oncogene homolog B1), a serine-threonine kinase involved in the MAPK signaling pathway. To understand anti-BRAF immunization, we sought to identify BRAF mutations in the peripheral blood lymphocytes (PBLs) of patients with RA. METHODS: We first cloned the major BRAF region...
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