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Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1

11 Mar 2019

Abstract excerpt

KIF1Bβ, a member of the kinesin superfamily of motor proteins, is a haploinsufficient tumor suppressor mapped to chromosome 1p36.2, which is frequently deleted in neural crest-derived tumors, including neuroblastoma and pheochromocytoma. While KIF1Bβ acts downstream of the nerve growth factor (NGF) pathway to induce apoptosis, further molecular functions of this gene product have largely been unexplored. In this...

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PMID: 30859632
DOI: 10.1002/mc.22997

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