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Article

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.

Autophagy - 1 Jul 2014

Nassif Melissa, Valenzuela Vicente, Rojas-Rivera Diego, Vidal René, Matus Soledad, Castillo Karen, Fuentealba Yerko, Kroemer Guido, Levine Beth, Hetz Claudio

Abstract excerpt

Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis of several neurodegenerative diseases. Mutations in the gene encoding S...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24905722
DOI: 10.4161/auto.28784
PMCID: PMC4203551

Genes

BECN1
SOD1
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24905722-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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