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Article

Genomic analysis of PLNTY-like tumor progression into epithelioid glioblastoma: a case report.

Acta neuropathologica communications - 8 Jan 2026

Mäntylä Sonja, Nurminen Anssi, Huovinen Sanna, Jaatinen Serafiina, Haapaniemi Teppo, Nurminen Riikka, Hermelo Ismaïl, Volz Stefanie, Maaß Kendra K, Pajtler Kristian W, Nordfors Kristiina, Haapasalo Hannu, Nykter Matti, Haapasalo Joonas, Rautajoki Kirsi J

Abstract excerpt

Polymorphous low-grade neuroepithelial tumors of the young (PLNTY) are slow- or non-progressing epileptogenic tumors, typically occurring in young adults. These tumors are highly calcified and exhibit both diffuse growth and oligodendroglioma-like patterns. Epithelioid glioblastomas (E-GB) are rare and aggressive variants of isocitrate dehydrogenase wildtype glioblastomas (GB), associated with poor overall...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41508055
DOI: 10.1186/s40478-025-02209-3
PMCID: PMC12874860

Genes

BRAF
CDKN2A
CD34
FOXRED2
GNS
SSTR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.Semantic proximity Read ↗

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