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Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa

25 Jan 2016

Abstract excerpt

The macrolide antibiotic, azithromycin (AZM), has been reported to improve the clinical outcome of cystic fibrosis patients, many of whom are chronically-infected with Pseudomonas aeruginosa. However, the highest clinically-achievable concentrations of this drug are well-below the minimum inhibitory concentration for P. aeruginosa, raising the question of why AZM exhibits therapeutic activity. One possibility...

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PMID: 26808156
DOI: 10.1371/journal.pone.0147698

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