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Article

Effects of Antibiotics on Quorum Sensing in <i>Pseudomonas aeruginosa</i>

22 Jul 2008

Abstract excerpt

During infection, Pseudomonas aeruginosa employs bacterial communication (quorum sensing [QS]) to coordinate the expression of tissue-damaging factors. QS-controlled gene expression plays a pivotal role in the virulence of P. aeruginosa, and QS-deficient mutants cause less severe infections in animal infection models. Treatment of cystic fibrosis (CF) patients chronically infected with P. aeruginosa with the...

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PMID: 18644954
DOI: 10.1128/aac.01230-07

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