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Article

Impact of pre-existing drug resistance on risk of virological failure in South Africa.

The Journal of antimicrobial chemotherapy - 12 May 2021

Li Jonathan Z, Stella Natalia, Choudhary Manish C, Javed Aneela, Rodriguez Katherine, Ribaudo Heather, Moosa Mahomed-Yunus, Brijkumar Jay, Pillay Selvan, Sunpath Henry, Noguera-Julian Marc, Paredes Roger, Johnson Brent, Edwards Alex, Marconi Vincent C, Kuritzkes Daniel R

Abstract excerpt

OBJECTIVES: There is conflicting evidence on the impact of pre-existing HIV drug resistance mutations (DRMs) in patients infected with non-B subtype virus. METHODS: We performed a case-cohort substudy of the AIDS Drug Resistance Surveillance Study, which enrolled South African patients initiating first-line efavirenz/emtricitabine/tenofovir. Pre-ART DRMs were detected by Illumina sequencing of HIV pol and DRMs...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33693678
DOI: 10.1093/jac/dkab062
PMCID: PMC8599859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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