Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study.

doi:10.1016/S1473-3099(16)30469-8

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Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study.

The Lancet. Infectious diseases - 1 Mar 2017

Gregson John, Kaleebu Pontiano, Marconi Vincent C, van Vuuren Cloete, Ndembi Nicaise, Hamers Raph L, Kanki Phyllis, Hoffmann Christopher J, Lockman Shahin, Pillay Deenan, de Oliveira Tulio, Clumeck Nathan, Hunt Gillian, Kerschberger Bernhard, Shafer Robert W, Yang Chunfu, Raizes Elliot, Kantor Rami, Gupta Ravindra K

Abstract excerpt

BACKGROUND: HIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhibitor drugs has been identified in sub-Saharan Africa in patients with virological failure of first-line combination antiretroviral therapy (ART) containing the modern nucleoside reverse transcriptase inhibitor tenofovir. We aimed to investigate the prevalence and correlates of thymidine analogue mutations (TAM) in...

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PMID: 27914856
DOI: 10.1016/S1473-3099(16)30469-8
PMCID: PMC5421555

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