Article
Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population.
PloS one - 1 Jan 2016
Maeda Yasuhiro, Migita Kiyoshi, Higuchi Osamu, Mukaino Akihiro, Furukawa Hiroshi, Komori Atsumasa, Nakamura Minoru, Hashimoto Satoru, Nagaoka Shinya, Abiru Seigo, Yatsuhashi Hiroshi, Matsuo Hidenori, Kawakami Atsushi, Yasunami Michio, Nakane Shunya
Abstract excerpt
BACKGROUND/AIMS: Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from...
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