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Article

Essential role of proteasomes in maintaining self-renewal in neural progenitor cells.

Scientific reports - 25 Jan 2016

Zhao Yunhe, Liu Xueqin, He Zebin, Niu Xiaojie, Shi Weijun, Ding Jian M, Zhang Li, Yuan Tifei, Li Ang, Yang Wulin, Lu Li

Abstract excerpt

Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent phenotypes induced by intensive cell replications, as previously demonstrated in human bone marrow stromal cells. In this study, we investigated the role of proteasomes in self-renewal of neural...

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Identifiers

PMID: 26804982
DOI: 10.1038/srep19752
PMCID: PMC4726439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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