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Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

25 Nov 2019

Abstract excerpt

Cellular senescence, a stress-induced irreversible cell cycle arrest, has been defined for mitotic cells and is implicated in aging of replicative tissues. Age-related functional decline in the brain is often attributed to a failure of protein homeostasis (proteostasis), largely in postmitotic neurons, which accordingly is a process distinct by definition from senescence. It is nevertheless possible that...

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PMID: 31762159
DOI: 10.1111/acel.13071

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