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Article

Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2015

Hechtman Jaclyn F, Liu Weiguo, Sadowska Justyna, Zhen Lisa, Borsu Laetitia, Arcila Maria E, Won Helen H, Shah Ronak H, Berger Michael F, Vakiani Efsevia, Shia Jinru, Klimstra David S

Abstract excerpt

The biological relevance of histological subtyping of ampullary carcinoma into intestinal vs pancreaticobiliary types remains to be determined. In an effort to molecularly profile these subtypes of ampullary carcinomas, we conducted a two-phase study. In the discovery phase, we identified 18 panc...

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Identifiers

PMID: 25975284
DOI: 10.1038/modpathol.2015.57
PMCID: PMC4977532

Genes

ERBB2
KRAS
APC
EGFR
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25975284-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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