Article
Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma.
Gut - 7 Apr 2025
Zhuravleva Ekaterina, Lewinska Monika, O'Rourke Colm J, Pea Antonio, Rashid Asif, Hsing Ann W, Taranta Andrzej, Chang David, Gao Yu-Tang, Koshiol Jill, Oliveira Rui Caetano, Andersen Jesper B
Abstract excerpt
BACKGROUND AND OBJECTIVE: Ampullary carcinoma (AMPAC) taxonomy is based on morphology and immunohistochemistry. This classification lacks prognostic reliability and unique genetic associations. We applied an approach of integrative genomics characterising patients with AMPAC exploring molecular subtypes that may guide personalised treatments. DESIGN: We analysed the mutational landscapes of 170 patients with...
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