Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer.

doi:10.1016/j.jtho.2016.01.009

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Article

Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2016

Pelosi Giuseppe, Gasparini Patrizia, Conte Davide, Fabbri Alessandra, Perrone Federica, Tamborini Elena, Pupa Serenella M, Ciravolo Valentina, Caserini Roberto, Rossi Giulio, Cavazza Alberto, Papotti Mauro, Nakatani Yukio, Maisonneuve Patrick, Pastorino Ugo, Sozzi Gabriella

Abstract excerpt

INTRODUCTION: Genetic alterations suitable for targeted therapy are poorly known issues in pulmonary sarcomatoid carcinoma (PSC), an uncommon and life-threatening family of non-small cell lung cancers. METHODS: Ninety-eight PSCs were assessed for MNNG HOS Transforming gene (MET) and anaplastic lymphoma receptor tyrosine kinase gene (ALK) status by fluorescence in situ hybridization (FISH) and for relevant protein...

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PMID: 26804638
DOI: 10.1016/j.jtho.2016.01.009

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