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Article

Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2012

Tanaka Aya, Sueoka-Aragane Naoko, Nakamura Tomomi, Takeda Yuji, Mitsuoka Masahiro, Yamasaki Fumio, Hayashi Shinichiro, Sueoka Eisaburo, Kimura Shinya

Abstract excerpt

MET, a receptor tyrosine kinase for hepatocyte growth factor, is associated with tumor progression and acquired resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI). Therefore, MET gene alterations could be both prognostic and predictive. Fluorescence in situ hybridization (FISH) is one method for assessing gene alteration, but the frequency of positive cases varies due to a lack of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21733594
DOI: 10.1016/j.lungcan.2011.06.004

Genes

MET
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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