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Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification.

Genetic testing and molecular biomarkers - 1 Mar 2016

Vijzelaar Raymon, van der Zwan Ellen, van Gammeren Adriaan, Yilmaz Rizkat, Verheul Alice, van Hoogstraten Ingrid, de Baar Ellen, Schrauwen Lianne, Kortlandt Wouter

Abstract excerpt

BACKGROUND: Genotyping of HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 is important in celiac disease (CD). The absence of these three genotypes has a strong negative predictive value. METHODS: We designed multiplex ligation-dependent probe amplification (MLPA) for the combined detection of HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8. The MLPA probe mix was validated against a set of 59 samples characterized by conventional...

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Identifiers

PMID: 26798991
DOI: 10.1089/gtmb.2015.0233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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