Article
Rapid, Loop-Mediated Isothermal Amplification Detection of Celiac Disease Risk Alleles.
The Journal of molecular diagnostics : JMD - 1 May 2018
Erlichster Michael, Tye-Din Jason A, Varney Michael D, Skafidas Efstratios, Kwan Patrick
Abstract excerpt
Human leukocyte antigen (HLA) genotyping has become a useful investigation in the diagnostic work-up of celiac disease (CD), with utility in risk stratification and screening. However, broad application of this technology has been hindered by the cost and time burden of conventional laboratory-based assays. We have developed and validated CD-loop-mediated isothermal amplification (CD-LAMP), a LAMP assay, which...
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