Article
A multiplex assay to rapidly exclude HLA-DQ2.5 and HLA-DQ8 expression in patients at risk for celiac disease.
Clinical chemistry and laboratory medicine - 1 Jun 2013
van Beek Ellen M, Roelandse-Koop Elianne A, Vijzelaar Raymon, Yilmaz Rizkat, van Hoogstraten Ingrid M W, Schreurs Marco W J, Verheul Alice A M, van Houte Arend Jan, Kortlandt Wouter
Abstract excerpt
BACKGROUND: Celiac disease (CD) is an inflammatory disorder of the small intestine induced by gluten ingestion. CD has a strong genetic association with human leukocyte antigen (HLA)-DQ2.5 and HLA-DQ8. The absence of HLA-DQ2.5 and HLA-DQ8 has a strong negative predictive value for CD. Genetic scr...
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