Article
A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.
Thorax - 1 Apr 2016
Spanjer Anita I R, Menzen Mark H, Dijkstra Akkelies E, van den Berge Maarten, Boezen H Marike, Nickle David C, Sin Don D, Bossé Yohan, Brandsma Corry-Anke, Timens Wim, Postma Dirkje S, Meurs Herman, Heijink Irene H, Gosens Reinoud
Abstract excerpt
RATIONALE: We have previously shown increased expression of the Frizzled-8 receptor of the Wingless/integrase-1 (WNT) signalling pathway in COPD. Here, we investigated if the Frizzled-8 receptor has a functional role in airway inflammation associated with chronic bronchitis. METHODS: Acute cigarette-smoke-induced airway inflammation was studied in wild-type and Frizzled-8-deficient mice. Genetic association...
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