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Article

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells.

Cancer letters - 28 Mar 2016

Sharma Bhawna, Varney Michelle L, Saxena Sugandha, Wu Lingyun, Singh Rakesh K

Abstract excerpt

CXCR2 and its ligands have been shown to play an important role in tumor angiogenesis, therapy resistance and progression. In this study, we investigated whether CXCR2 ligands are responsible for the survival advantage and metastasis of drug-resistant cells and examined the underlying mechanism(s) doxorubicin or paclitaxel resistant mammary tumor cells. Our results demonstrated that drug-resistant Cl66 cells...

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Source

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Identifiers

PMID: 26797460
DOI: 10.1016/j.canlet.2015.12.011
PMCID: PMC4821546

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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