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Article

The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24‑ phenotype.

Molecular medicine reports - 1 Dec 2016

Zhao Haishan, Tang Hongtao, Xiao Qinghuan, He Miao, Zhao Lin, Fu Yingzi, Wu Huizhe, Yu Zhaojin, Jiang Qian, Yan Yuanyuan, Jin Feng, Wei Minjie

Abstract excerpt

Cancer stem cells (CSCs) have been suggested to serve an important role in tumor recurrence and metastasis in breast cancer. The hedgehog (Hh) signaling pathway is essential for the maintenance of breast CSCs. The present study used immunohistochemistry to investigate the expression of Patched (PTCH) and Gli1, which are the main components of the Hh signaling pathway, as well as the expression of cluster of...

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Identifiers

PMID: 27779682
DOI: 10.3892/mmr.2016.5856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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