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Article

Lung cancer stem cells: The root of resistance.

Cancer letters - 28 Mar 2016

MacDonagh Lauren, Gray Steven G, Breen Eamon, Cuffe Sinead, Finn Stephen P, O'Byrne Kenneth J, Barr Martin P

Abstract excerpt

In the absence of specific treatable mutations, platinum-based chemotherapy remains the gold standard of treatment for lung cancer patients. However, 5-year survival rates remain poor due to the development of resistance and eventual relapse. Resistance to conventional cytotoxic therapies presents a significant clinical challenge in the treatment of this disease. The cancer stem cell (CSC) hypothesis suggests...

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Source

Identifiers

PMID: 26797015
DOI: 10.1016/j.canlet.2016.01.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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