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The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.

1 Dec 2012

Abstract excerpt

The cancer stem-cell (CSC) hypothesis suggests that there is a small subset of cancer cells that are responsible for tumor initiation and growth, possessing properties such as indefinite self-renewal, slow replication, intrinsic resistance to chemotherapy and radiotherapy, and an ability to give rise to differentiated progeny. Through the use of xenotransplantation assays, putative CSCs have been identified in...

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PMID: 23154562
DOI: 10.1097/jto.0b013e31826bfbc6

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