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Article

A new crystal form of human transthyretin obtained with a curcumin derived ligand.

Journal of structural biology - 1 Apr 2016

Polsinelli Ivan, Nencetti Susanna, Shepard William, Ciccone Lidia, Orlandini Elisabetta, Stura Enrico A

Abstract excerpt

Transthyretin (TTR), a 54kDa homotetrameric protein that transports thyroxine (T4), has been associated with clinical cases of TTR amyloidosis for its tendency to aggregate to form fibrils. Many ligands with a potential to inhibit fibril formation have been studied by X-ray crystallography in complex with TTR. Unfortunately, the ligand is often found in ambiguous electron density that is difficult to interpret....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26796656
DOI: 10.1016/j.jsb.2016.01.007

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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