Article
Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.
PloS one - 1 Jan 2016
Pietilä Ilkka, Prunskaite-Hyyryläinen Renata, Kaisto Susanna, Tika Elisavet, van Eerde Albertien M, Salo Antti M, Garma Leonardo, Miinalainen Ilkka, Feitz Wout F, Bongers Ernie M H F, Juffer André, Knoers Nine V A M, Renkema Kirsten Y, Myllyharju Johanna, Vainio Seppo J
Abstract excerpt
The Wnts can be considered as candidates for the Congenital Anomaly of Kidney and Urinary Tract, CAKUT diseases since they take part in the control of kidney organogenesis. Of them Wnt5a is expressed in ureteric bud (UB) and its deficiency leads to duplex collecting system (13/90) uni- or bilateral kidney agenesis (10/90), hypoplasia with altered pattern of ureteric tree organization (42/90) and lobularization...
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