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Article

The aryl hydrocarbon receptor promotes aging phenotypes across species.

Scientific reports - 21 Jan 2016

Eckers Anna, Jakob Sascha, Heiss Christian, Haarmann-Stemmann Thomas, Goy Christine, Brinkmann Vanessa, Cortese-Krott Miriam M, Sansone Roberto, Esser Charlotte, Ale-Agha Niloofar, Altschmied Joachim, Ventura Natascia, Haendeler Judith

Abstract excerpt

The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR ligands promote atherosclerosis, an age-associated vascular disease. Therefore, we investigated the role of AhR in vascular functionality and aging. We report a lower pulse wave velocity in young and old AhR-deficient mice, indicative of...

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Identifiers

PMID: 26790370
DOI: 10.1038/srep19618
PMCID: PMC4726214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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