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Article

An endogenous aryl hydrocarbon receptor ligand induces preeclampsia-like phenotypes in rats.

The Journal of physiology - 1 Jan 2025

Zhao Ying-Jie, Zhou Chi, Zhang Si-Yan, Mishra Jay S, Li Hui-Hui, Lei Wei, Wang Kai, Kumar Sathish, Zheng Jing

Abstract excerpt

Preeclampsia (PE) is a hypertensive disorder during human pregnancy. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Exogenous and endogenous AhR ligands can induce hypertension in male rats and mice. Herein, using rats as a model, we tested the hypothesis that over-regulation of endogenous AhR ligands during pregnancy impairs vascular functions by disrupting the transcriptome in the...

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Identifiers

PMID: 39652430
DOI: 10.1113/JP287503
PMCID: PMC11737537

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