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Article

Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2016

Thompson Ella R, Rowley Simone M, Li Na, McInerny Simone, Devereux Lisa, Wong-Brown Michelle W, Trainer Alison H, Mitchell Gillian, Scott Rodney J, James Paul A, Campbell Ian G

Abstract excerpt

PURPOSE: Gene panel sequencing is revolutionizing germline risk assessment for hereditary breast cancer. Despite scant evidence supporting the role of many of these genes in breast cancer predisposition, results are often reported to families as the definitive explanation for their family history. We assessed the frequency of mutations in 18 genes included in hereditary breast cancer panels among index cases from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26786923
DOI: 10.1200/JCO.2015.63.7454

Genes

BRCA1
BRCA2
PALB2
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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