Article
Routine use of gene panel testing in hereditary breast cancer should be performed with caution.
Critical reviews in oncology/hematology - 1 Dec 2016
van Marcke Cedric, De Leener Anne, Berlière Martine, Vikkula Miikka, Duhoux Francois P
Abstract excerpt
Breast cancer is the most frequent cancer occurring in women. Ten percent of these cancers are considered hereditary. Among them, 30% are attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. Other genes of lower penetrance are also known, explaining together up to 40% of the hereditary risk of breast cancer. New techniques, such as next-generation sequencing, allow the simultaneous...
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