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Article

Bcl‐xL as prognostic marker and potential therapeutic target in cholangiocarcinoma

19 Aug 2022

Abstract excerpt

Abstract Intrahepatic, perihilar, and distal cholangiocarcinoma (iCCA, pCCA, dCCA) are highly malignant tumours with increasing mortality rates due to therapy resistances. Among the mechanisms mediating resistance, overexpression of anti‐apoptotic Bcl‐2 proteins (Bcl‐2, Bcl‐xL, Mcl‐1) is particularly important. In this study, we investigated whether antiapoptotic protein patterns are prognostically relevant and...

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PMID: 35983950
DOI: 10.1111/liv.15392

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