Article
Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.
Neoplasia (New York, N.Y.) - 1 Feb 2017
Gong Yongxing, Schumacher Steven E, Wu Wei H, Tang Fanying, Beroukhim Rameen, Chan Timothy A
Abstract excerpt
Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approximately 10,000 tumor genomes uncovers a striking pattern of mutual exclusivity between PARK2...
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