Article
The ins and outs of muscle stem cell aging.
Skeletal muscle - 1 Jan 2016
Brack Andrew S, Muñoz-Cánoves Pura
Abstract excerpt
Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the environment and/or to cell-intrinsic mechanisms associated to aging has been a matter of intense debate. Furthermore, while some groups support that satellite cell aging is reversible by a youthful environment,...
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