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Article

The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs.

Biomaterials - 1 Feb 2012

Chen Lei, Xiao Zhifeng, Meng Yue, Zhao Yannan, Han Jin, Su Guannan, Chen Bing, Dai Jianwu

Abstract excerpt

Three-dimensional (3D) culture could partially simulate in vivo conditions. In this work, we developed a 3D collagen scaffold to investigate cellular properties of MCF-7 cells. The porous scaffolds not only induced the diversification of cell morphologies but also extended cell proliferation. The expression of pro-angiogenic growth factors and the transcriptions of matrix metalloproteinases (MMPs) were...

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Identifiers

PMID: 22078807
DOI: 10.1016/j.biomaterials.2011.10.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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