Article
A map of the interactome network of the metazoan C. elegans.
Science (New York, N.Y.) - 23 Jan 2004
Li Siming, Armstrong Christopher M, Bertin Nicolas, Ge Hui, Milstein Stuart, Boxem Mike, Vidalain Pierre-Olivier, Han Jing-Dong J, Chesneau Alban, Hao Tong, Goldberg Debra S, Li Ning, Martinez Monica, Rual Jean-François, Lamesch Philippe, Xu Lai, Tewari Muneesh, Wong Sharyl L, Zhang Lan V, Berriz Gabriel F, Jacotot Laurent, Vaglio Philippe, Reboul Jérôme, Hirozane-Kishikawa Tomoko, Li Qianru, Gabel Harrison W, Elewa Ahmed, Baumgartner Bridget, Rose Debra J, Yu Haiyuan, Bosak Stephanie, Sequerra Reynaldo, Fraser Andrew, Mango Susan E, Saxton William M, Strome Susan, Van Den Heuvel Sander, Piano Fabio, Vandenhaute Jean, Sardet Claude, Gerstein Mark, Doucette-Stamm Lynn, Gunsalus Kristin C, Harper J Wade, Cusick Michael E, Roth Frederick P, Hill David E, Vidal Marc
Abstract excerpt
To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally...
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