Article
Genetic signatures of HIV-1 envelope-mediated bystander apoptosis.
The Journal of biological chemistry - 31 Jan 2014
Joshi Anjali, Lee Raphael T C, Mohl Jonathan, Sedano Melina, Khong Wei Xin, Ng Oon Tek, Maurer-Stroh Sebastian, Garg Himanshu
Abstract excerpt
The envelope (Env) glycoprotein of HIV is an important determinant of viral pathogenesis. Several lines of evidence support the role of HIV-1 Env in inducing bystander apoptosis that may be a contributing factor in CD4(+) T cell loss. However, most of the studies testing this phenomenon have been conducted with laboratory-adapted HIV-1 isolates. This raises the question of whether primary Envs derived from...
Topics
- Acquired Immunodeficiency Syndrome
- Antibodies, Neutralizing
- Apoptosis
- Bystander Effect
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- HeLa Cells
- High-Throughput Nucleotide Sequencing
- Humans
- Phenotype