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Article

Genetic signatures of HIV-1 envelope-mediated bystander apoptosis.

The Journal of biological chemistry - 31 Jan 2014

Joshi Anjali, Lee Raphael T C, Mohl Jonathan, Sedano Melina, Khong Wei Xin, Ng Oon Tek, Maurer-Stroh Sebastian, Garg Himanshu

Abstract excerpt

The envelope (Env) glycoprotein of HIV is an important determinant of viral pathogenesis. Several lines of evidence support the role of HIV-1 Env in inducing bystander apoptosis that may be a contributing factor in CD4(+) T cell loss. However, most of the studies testing this phenomenon have been conducted with laboratory-adapted HIV-1 isolates. This raises the question of whether primary Envs derived from...

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Share to Acquired Immunodeficiency Syndrome
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bystander Effect

Share to CD4-Positive T-Lymphocytes

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Envelope Protein gp120

Share to HIV Envelope Protein gp41

Share to Receptors, CCR5

Source

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Identifiers

PMID: 24265318
DOI: 10.1074/jbc.M113.514018
PMCID: PMC3908386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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