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Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review

27 May 2023

Abstract excerpt

Geranylgeranoic acid (GGA) was first reported in 1983 as one of the mevalonic acid metabolites, but its biological significance was not studied for a long time. Our research on the antitumor effects of retinoids led us to GGA, one of the acyclic retinoids that induce cell death in human hepatoma-derived cell lines. We were able to demonstrate the presence of endogenous GGA in various tissues of male rats,...

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PMID: 37247782
DOI: 10.1016/j.jlr.2023.100396

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