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Signatures of negative frequency dependent selection in colonisation factors and the evolution of a multi-drug resistant lineage of <i>Escherichia coli</i>

2018-08-25

Abstract excerpt

Escherichia coli is a major cause of bloodstream and urinary tract infections globally. The wide dissemination of multi-drug resistant (MDR) strains of extra-intestinal pathogenic E. coli (ExPEC) poses a rapidly increasing public health burden due to narrowed treatment options and increased risk of failure to clear an infection. Here, we present a detailed population genomic analysis of the ExPEC ST131 clone, in...

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Identifiers and source

Literature Corpus work
f42f8487-e043-5afa-938f-94056f7f3c23
DOI
10.1101/400374
Open publication

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Signatures of negative frequency dependent selection in colonisation factors and the evolution of a multi-drug resistant lineage of <i>Escherichia coli</i>DOI 10.1101/400374
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