A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis.

doi:10.1371/journal.pone.0146435

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Article

A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis.

PloS one - 1 Jan 2016

Markowitz Sanford D, Nock Nora L, Schmit Stephanie L, Stadler Zsofia K, Joseph Vijai, Zhang Lu, Willis Joseph E, Scacheri Peter, Veigl Martina, Adams Mark D, Raskin Leon, Sullivan John F, Stratton Kelly, Shia Jinru, Ellis Nathan, Rennert Hedy S, Manschreck Christopher, Li Li, Offit Kenneth, Elston Robert C, Rennert Gadi, Gruber Stephen B

Abstract excerpt

We tested for germline variants showing association to colon cancer metastasis using a genome-wide association study that compared Ashkenazi Jewish individuals with stage IV metastatic colon cancers versus those with stage I or II non-metastatic colon cancers. In a two-stage study design, we demonstrated significant association to developing metastatic disease for rs60745952, that in Ashkenazi discovery and...

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PMID: 26751797
DOI: 10.1371/journal.pone.0146435
PMCID: PMC4709047

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