Article
Genetic variants associated with colorectal brain metastases susceptibility and survival.
The pharmacogenomics journal - 1 Jan 2017
Stremitzer S, Berghoff A S, Volz N B, Zhang W, Yang D, Stintzing S, Ning Y, Sunakawa Y, Yamauchi S, Sebio A, Matsusaka S, Okazaki S, Hanna D, Parekh A, Mendez A, Berger M D, El-Khoueiry R, Birner P, Preusser M, Lenz H-J
Abstract excerpt
Colorectal brain metastases (BM) are rare (1-2%) and a late-stage disease manifestation. Molecular mechanisms for BM development are not well understood. We tested whether variants within genes involved in overcoming the blood-brain barrier (BBB) are associated with BM susceptibility and survival in patients with BM. Germline single-nucleotide polymorphisms (SNPs, n=17) in seven genes (CXCR4, MMP9, ST6GALNAC5,...
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