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Article

CFTR and colorectal cancer susceptibility: an urgent need for further studies.

Trends in cancer - 1 Oct 2024

Spelier S, Derksen S, Hofland R, Beekman J M, Yetkin-Arik B

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

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Identifiers

PMID: 39147661
DOI: 10.1016/j.trecan.2024.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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