Article
CFTR dysregulation drives active selection of the gut microbiome.
PLoS pathogens - 1 Jan 2020
Meeker Stacey M, Mears Kevin S, Sangwan Naseer, Brittnacher Mitchell J, Weiss Eli J, Treuting Piper M, Tolley Nicholas, Pope Christopher E, Hager Kyle R, Vo Anh T, Paik Jisun, Frevert Charles W, Hayden Hillary S, Hoffman Lucas R, Miller Samuel I, Hajjar Adeline M
Abstract excerpt
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI inflammation and nutrient malabsorption. However, whether this dysbiosis is caused by mutations in the CFTR gene, the underlying defect in CF, or whether CF-associated dysbiosis augments GI disease was...
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