A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.

doi:10.1136/jnnp-2015-311541

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Article

A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2016

Watanabe Hazuki, Atsuta Naoki, Hirakawa Akihiro, Nakamura Ryoichi, Nakatochi Masahiro, Ishigaki Shinsuke, Iida Aritoshi, Ikegawa Shiro, Kubo Michiaki, Yokoi Daichi, Watanabe Hirohisa, Ito Mizuki, Katsuno Masahisa, Izumi Yuishin, Morita Mitsuya, Kanai Kazuaki, Taniguchi Akira, Aiba Ikuko, Abe Koji, Mizoguchi Koichi, Oda Masaya, Kano Osamu, Okamoto Koichi, Kuwabara Satoshi, Hasegawa Kazuko, Imai Takashi, Kawata Akihiro, Aoki Masashi, Tsuji Shoji, Nakashima Kenji, Kaji Ryuji, Sobue Gen

Abstract excerpt

OBJECTIVE: To classify the patterns of functional decline in patients with sporadic amyotrophic lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns. METHODS: We included 465 patients with sporadic ALS in the analysis and clustered the longitudinal functional scores in the registered patients, using a mixture approach of a non-linear mixed-effects model. We conducted a...

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PMID: 26746183
DOI: 10.1136/jnnp-2015-311541

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