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Article

Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity.

Brain : a journal of neurology - 21 Oct 2022

Benatar Michael, Granit Volkan, Andersen Peter M, Grignon Anne-Laure, McHutchison Caroline, Cosentino Stephanie, Malaspina Andrea, Wuu Joanne

Abstract excerpt

Amyotrophic lateral sclerosis, when viewed as a biological entity rather than a clinical syndrome, probably evolves along a continuum, with the initial clinically silent phase eventually evolving into clinically manifest amyotrophic lateral sclerosis. Since motor neuron degeneration is incremental and cumulative over time, it stands to reason that the clinical syndrome of amyotrophic lateral sclerosis is probably...

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PMID: 35594156
DOI: 10.1093/brain/awac185
PMCID: PMC9586537

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