Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype.

Respiratory research - 31 Aug 2012

Robinson Claire M, Neary Roisin, Levendale Ashleigh, Watson Chris J, Baugh John A

Abstract excerpt

BACKGROUND: Pulmonary fibrosis is a debilitating and lethal disease with no effective treatment options. Understanding the pathological processes at play will direct the application of novel therapeutic avenues. Hypoxia has been implicated in the pathogenesis of pulmonary fibrosis yet the precise...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Cell Hypoxia
Share to Collagen Type III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to DNA Modification Methylases

Share to Myofibroblasts

Share to Pulmonary Fibrosis

Share to Thy-1 Antigens

Source

Open in PubMed Open full text

Identifiers

PMID: 22938014
DOI: 10.1186/1465-9921-13-74
PMCID: PMC3519562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22938014-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype.PMID 22938014Read ↗

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.Semantic proximity Read ↗

TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts.Semantic proximity Read ↗

Epigenetics and the overhealing wound: the role of DNA methylation in fibrosisSemantic proximity Read ↗

Global Methylation Patterns in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

Epigenetic changes by DNA methylation in chronic and intermittent hypoxiaSemantic proximity Read ↗

Lung Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis Exhibit Genome-Wide Differences in DNA Methylation Compared to Fibroblasts from Nonfibrotic LungSemantic proximity Read ↗

Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the SolutionSemantic proximity Read ↗

Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation ( TET ) family, TET 1, in scleroderma fibroblastsSemantic proximity Read ↗

Transforming growth factor beta 1 induces methylation changes in lung fibroblastsSemantic proximity Read ↗

Humans with Pulmonary Arterial Hypertension display a global hypermethylation signature that worsens in patients who have a mutation in the gene encoding the methylation eraser, Tet Methylcytosine Dioxygenase 2 (TET2)Semantic proximity Read ↗

Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).Semantic proximity Read ↗

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.