Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation of TFPI-2 gene is not the sole cause of its silencing.

International journal of oncology - 1 Apr 2003

Rao Chilukuri N, Segawa Takehiko, Navari Jason R, Xu Linda, Srivastava Shiv, Moul Judd W, Phillips Benette

Abstract excerpt

TFPI-2 (tissue factor pathway inhibitor-2) is a serine protease inhibitor that may suppress tumor cell invasion and metastasis. TFPI-2 expression is often lost in cells derived from tumors of diverse organs. We have examined whether aberrant hypermethylation of the 5' end of the TFPI-2 gene is associated with its loss of expression. After 5-azacytidine treatment of three cell lines lacking TFPI-2 expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Blotting, Northern
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Reporter

Share to Glycoproteins

Share to Luciferases

Share to Sulfites

Source

Identifiers

PMID: 12632077

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Methylation of TFPI-2 gene is not the sole cause of its silencing.PMID 12632077Read ↗

The Role of Tissue Factor Pathway Inhibitor-2 in Cancer BiologySemantic proximity Read ↗

TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinomaSemantic proximity Read ↗

Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma†Semantic proximity Read ↗

Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cellsSemantic proximity Read ↗

Silencing of tissue factor pathway inhibitor‐2 gene in malignant melanomasSemantic proximity Read ↗

Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells.Semantic proximity Read ↗

Frequent hypermethylation of 5' flanking region of TIMP-2 gene in cervical cancer.Semantic proximity Read ↗

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.Semantic proximity Read ↗

Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques.Semantic proximity Read ↗

Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.