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Article

Inhibition of cross-species CXCR4 signaling by the small molecule IT1t impairs triple negative breast cancer early metastases in zebrafish

1 Jan 2016

Abstract excerpt

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides cell migration in physiological and pathological processes, including breast cancer metastasis. Although targeted...

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PMID: 26744352
DOI: 10.1242/dmm.023275

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