Article
The chemokine receptor CX₃CR1 is directly involved in the arrest of breast cancer cells to the skeleton.
Breast cancer research : BCR - 20 Sept 2011
Jamieson-Gladney Whitney L, Zhang Yun, Fong Alan M, Meucci Olimpia, Fatatis Alessandro
Abstract excerpt
INTRODUCTION: Skeletal metastases from breast adenocarcinoma are responsible for most of the morbidity and mortality associated with this tumor and represent a significant and unmet need for therapy. The arrival of circulating cancer cells to the skeleton depends first on the adhesive interactions with the endothelial cells lining the bone marrow sinusoids, and then the extravasation toward chemoattractant...
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