Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

doi:10.1093/nar/gkv1530

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Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

Nucleic acids research - 19 May 2016

Tak Yu Gyoung, Hung Yuli, Yao Lijing, Grimmer Matthew R, Do Albert, Bhakta Mital S, O'Geen Henriette, Segal David J, Farnham Peggy J

Abstract excerpt

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with increased risk for colorectal cancer (CRC). A molecular understanding of the functional consequences of this genetic variation is complicated because most GWAS SNPs are located in non-coding regions. We used epigenomic information to identify H3K27Ac peaks in HCT116 colon cancer cells that harbor SNPs...

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Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

Abstract excerpt

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