Article
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.
Pharmacogenetics and genomics - 1 Oct 2009
Jorgensen Andrea L, Al-Zubiedi Sameh, Zhang Jieying Eunice, Keniry Andrew, Hanson Anita, Hughes Dyfrig A, Eker Diane van, Stevens Lisa, Hawkins Karen, Toh Cheng H, Kamali Farhad, Daly Ann K, Fitzmaurice David, Coffey Alison, Williamson Paula R, Park Brian Kevin, Deloukas Panos, Pirmohamed Munir
Abstract excerpt
BACKGROUND: In this prospective cohort study, we have undertaken a comprehensive evaluation of clinical parameters along with variation in 29 genes (including CYP2C9 and VKORC1) to identify factors determining interindividual variability in warfarin response. METHODS: Consecutive patients (n=311) were followed up prospectively for 26 weeks. Several outcomes chosen to capture both warfarin efficacy and toxicity...
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